Randomized clinical trial (RCT)
Week 2, Part 1 Assignment
Use http://pubmed.gov to search for results, reported from randomized clinical trials (RCTs), regarding the effect of vitamin E on cardiovascular mortality in the general population. This means you need to make sure that you are searching for articles involving clinical trials (RCTs) that specifically investigate an association between vitamin E and cardiovascular mortality (not just cardiovascular disease).
As you conduct this search, notice how the pubmed article list that is generated, yielded from your search terms, drastically differs depending on the terms you use in your search. This is part of the assignment and it may take some time until you realize which terms to use in the search field that will yield the most relevant list of articles.
You will be graded on your ability to find the most relevant article list based on the key details for this search that we provided above. This is good practice for learning how to conduct a useful literature search.
You should include more than two articles for this assignment but a long list of articles is not required here bc this particular search will not generate a long list of relevant articles.
Once you find the most relevant list of articles, please create a Microsoft Word document to list, in a table, the relevant articles you have found in a table.
I am requesting that you create a table because it will help to compare and contrast the details across articles.
To receive full credit for this assignment, ALL of the following information should be very briefly included on your table for each article that you have found:
- full reference of the article
- study setting (briefly describe all three: study population, place and time)
- list the exposure (this is also known as the predictor or the determinant and, in the social sciences, it is known as the independent variable)
- list the outcome (In public health, the outcome is often the disease or public health condition of interest. In the social sciences, it is known as the dependent variable. Therefore, by “outcome”, this is not referring to the study’s findings here. You will report that for Question #6 below.)
- study design type (notice the study design type that is requested for this assignment)
- very brief description of the main findings
- Lastly, below the table that you create, be sure to write one sentence explaining what you think the effect of vitamin E is on cardiovascular mortality, based on this evidence that you have identified.
Then, to submit this Assignment, upload your one-page Microsoft Word document (with your table and one sentence) by clicking on Browse My Computer. After submitting, log back into Bb and open the file you submitted to ensure you submitted the correct file even if you received a Bb confirmation notification.
- Dear writer, please make sure the 7 requirements for this assignment.
- The article should be within 5 years and need the original articles attached please.
- This is an Epidemiology class assignment. Please let me know if you have any questions.
- Thank you so much!
BUY A PLAGIARISM-FREE PAPER HERE
Week 2: Part 1 Assignment
Students conduct article searches from various credible nursing databases to obtain evidence needed to address a particular clinical issue. This paper summarizes an article on a randomized clinical trial (RCT) investigating the connection between vitamin E and cardiovascular mortality. This paper provides a table of selected article based on the topic ‘effect of vitamin E on cardiovascular mortality’, and subsequent analysis on their relation to the topic.
Article full reference |
Study Setting (Population, Place & Time) |
Exposure (Independent variable) |
List of Outcome (disease/public health condition of interest)…Dependent variable |
Study Design /Type |
Brief description of main findings |
|
Article 1 |
da Costa Hime, L. D. F. C., Carvalho Lopes, C. M., Roa, C. L., Zuchelo, L. T. S., Baracat, E. C., de Andrade, J., & Soares, J. M. (2021). Is there a beneficial effect of gamma-linolenic acid supplementation on body fat in postmenopausal hypertensive women? A prospective randomized double-blind placebo-controlled trial. Menopause, 28(6), 699–705. https://doi.org/10.1097/gme.0000000000001740 |
This article was published in 2021. And utilized 96 women who were divided in 2 groups where one was treated with Vitamin E only (Placebo) while the other was treated with vitamin E + borage oil rich in gamma-linoleic acid. The research as run for 6 months with repeated measures being done at varying times. |
With reference to the study the independent variable comprises the borage oil rich in gamma-linoleic acid + vitamin E |
The independent variable comprises of systemic arterial hypertension and obesity which are key health concerns and increases cardiovascular mortality |
The study was identified as a randomized clinical trial which contain a control group compared to the other.The research deployed a double-blind placebo controlled and randomized study |
Drawing from the article, it was established that, there was significant reduction of diastolic and systolic pressures among the first group unlike the case with the placebo group. |
Article II |
Lee, C. H., Chan, R. S., Wan, H. Y., Woo, Y. C., Cheung, C. Y., Fong, C. H., … & Lam, K. S. (2018). Dietary intake of antioxidant vitamins A, C, and E Is inversely associated with adverse cardiovascular outcomes in Chinese—A 22-years population-based prospective study. Nutrients, 10(11), 1664. Doi:10.3390/nu10111664 |
The study was conducted at Hong Kong Chinese between 1995 and 1996. It involved 875 Chinese participants |
The independent variable for this study was dietary intake of antioxidant vitamins (A, C, and E), while the dependent variable was adverse cardiovascular outcomes, including deaths, non-fatal myocardial infarction, and non-fatal stroke. |
The social problem that necessitated this study was a high prevalence of cardiovascular diseases and related adverse outcomes, including death in Hong Kong, China. |
A prospective population-based study design. |
The study findings indicated that dietary intakes of vitamin A, C, and E prevent adverse cardiovascular outcomes, including deaths. |
Article III |
Li, H., He, P., Lin, T., Guo, H., Li, Y., Song, Y., Wang, B., Liu, C., Liu, L., Li, J., Zhang, Y., Huo, Y., Zhou, H., Yang, Y., Ling, W., Wang, X., Zhang, H., Xu, X., & Qin, X. (2020). Association between plasma retinol levels and the risk of all‐cause mortality in general hypertensive patients: A nested case‐control study. The Journal of Clinical Hypertension, 22(5), 906–913. https://doi.org/10.1111/jch.13866 |
The study was conducted in 32 different communities in Anhui Jiangsu provinces in china, with all-cause mortality the primary outcome in focus. |
Drawing from the research, the independent variable comprised the lower retinol level |
The dependent variable was the all-cause mortality was the main outcome in this analysis, which included death due to any reason |
The study was a case-control a randomized, double-blind, controlled trial. all-cause mortality was the main outcome in this analysis, which included death due to any reason |
The researches main findings established that, there was relationship between retinol and the risk of all-cause mortality among the hypertensive adults. Optimizing individual’s retinols in blood would reduce the mortality risk. |
Drawing from the used articles, the studies established diverse findings where the use of vitamin has diverse impact in the used population. for example, vitamin E prevents cardiovascular mortality in the general population (Lee et al., 2018)
REFERENCES
da Costa Hime, L. D. F. C., Carvalho Lopes, C. M., Roa, C. L., Zuchelo, L. T. S., Baracat, E. C., de Andrade, J., & Soares, J. M. (2021). Is there a beneficial effect of gamma-linolenic acid supplementation on body fat in postmenopausal hypertensive women? A prospective randomized double-blind placebo-controlled trial. Menopause, 28(6), 699–705. https://doi.org/10.1097/gme.0000000000001740
Lee, C. H., Chan, R. S., Wan, H. Y., Woo, Y. C., Cheung, C. Y., Fong, C. H., … & Lam, K. S. (2018). Dietary intake of antioxidant vitamins A, C, and E Is inversely associated with adverse cardiovascular outcomes in Chinese—A 22-years population-based prospective study. Nutrients, 10(11), 1664. Doi:10.3390/nu10111664
Li, H., He, P., Lin, T., Guo, H., Li, Y., Song, Y., Wang, B., Liu, C., Liu, L., Li, J., Zhang, Y., Huo, Y., Zhou, H., Yang, Y., Ling, W., Wang, X., Zhang, H., Xu, X., & Qin, X. (2020). Association between plasma retinol levels and the risk of all‐cause mortality in general hypertensive patients: A nested case‐control study. The Journal of Clinical Hypertension, 22(5), 906–913. https://doi.org/10.1111/jch.13866